Description

Big Endothelin-1 (Rat) Trifluoroacetate Salt is a high-purity, synthetic peptide analog of the potent vasoconstrictor endothelin-1, specifically derived from the rat sequence. This compound is a critical research-grade biochemical tool for investigating cardiovascular physiology, hypertension, and endothelin receptor signaling pathways. It is essential for pharmaceutical R&D, academic research, and biotechnology applications focused on vascular biology and drug discovery.

Application

• Biomedical Research: Used as a standard or agonist in studies of endothelin receptor (ETA and ETB) function, vascular smooth muscle contraction, and blood pressure regulation.
• Drug Discovery & Screening: Serves as a key pharmacological tool for the in vitro and ex vivo validation of potential endothelin receptor antagonists and cardiovascular therapeutics.
• Cell Signaling Studies: Applied in cell culture assays to study intracellular calcium mobilization, second messenger systems (e.g., IP3), and gene expression changes induced by endothelin-1.
• Animal Model Studies: Utilized in preclinical research involving rat models to study the pathophysiological role of endothelin in diseases like pulmonary arterial hypertension, heart failure, and chronic kidney disease.
• Diagnostic Development: May be employed in the development and calibration of immunoassays (e.g., ELISA) designed to detect endothelin-1 or related peptides.

Basic Information

Item	Detail
Product Name	Big Endothelin-1 (Rat) Trifluoroacetate Salt
CAS No.	2243219-82-9
Molecular Formula	C109H159N31O32 • xC2HF3O2
Molecular Weight	~2380.6 g/mol (Free base)
Synonyms	Big ET-1 (Rat); Endothelin-1 (1-38), rat; ET-1 (1-38), rat; Big Endothelin-1 rat; Rat Big Endothelin-1; rBigET-1; CAS 2243219-82-9; Trifluoroacetate salt of Big Endothelin-1 (Rat)
EINECS	Contact for details

Quality Control

Every batch of Big Endothelin-1 (Rat) Trifluoroacetate Salt is manufactured and analyzed under strict quality management protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Our quality commitment includes comprehensive analytical testing via HPLC and mass spectrometry. A detailed Certificate of Analysis (COA) providing purity, identity, and content data is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Trifluoroacetate Content (HPLC/NMR)	≤ 15%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.