Description

(Thr1)-C-Jun (11-23) Trifluoroacetate Salt is a chemically synthesized peptide fragment derived from the c-Jun protein, a key component of the AP-1 transcription factor complex. This high-purity reference standard is critical for biochemical research, enabling precise study of phosphorylation events and protein-protein interactions that regulate gene expression. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on signal transduction pathways, oncology, and cellular stress responses.

Application

• Biochemical Research Standard: Serves as a critical reference material for the study of AP-1 transcription factor activity and c-Jun phosphorylation at the threonine 91/93 site.
• Kinase Assay Substrate: Used as a specific substrate in in vitro kinase assays to screen for and characterize JNK (c-Jun N-terminal kinase) and other MAPK family enzyme activity.
• Antibody Production & Validation: Acts as an immunogen or a validation tool for developing and testing phospho-specific antibodies targeting the Thr91/93 region of c-Jun.
• Cell Signaling Pathway Analysis: Employed in competitive binding studies and pull-down assays to investigate interactions within the MAPK/JNK signaling cascade.
• Pharmaceutical Development: Supports drug discovery programs targeting dysregulated AP-1 activity in conditions like cancer, inflammation, and neurodegenerative diseases.
• Proteomics & Mass Spectrometry: Functions as a calibrant or standard in LC-MS/MS workflows for the identification and quantification of c-Jun and its post-translational modifications.

Basic Information

Product Name	(Thr1)-C-Jun (11-23) Trifluoroacetate Salt
CAS No.	2243207-05-6
Molecular Formula	C66H111N21O22 • xC2HF3O2
Molecular Weight	~1550.7 g/mol (free peptide base)
Synonyms	Phospho-c-Jun (Thr91/93) Peptide (11-23); c-Jun (11-23) Phosphothreonine Peptide; AP-1 c-Jun Phosphopeptide Fragment; JNK Substrate Peptide; c-Jun pThr91/93 (11-23); MAPK Substrate Peptide; LQLKpTPPpTPGGSR; pThr91/93-c-Jun (11-23)
EINECS	Contact for details

Quality Control

Every batch of (Thr1)-C-Jun (11-23) Trifluoroacetate Salt is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment aligns with standards expected for research-grade biochemicals. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), peptide content, mass spectrometry (MS) confirmation, and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical composition
Solubility	Soluble in water or aqueous buffers
Single Spot on TLC	Pass

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.