Description

Cyclopropanepropanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Methylamino]-, (αr)- is a sophisticated, non-natural amino acid derivative featuring a cyclopropane ring and an Fmoc-protected amine group. This compound is of critical importance in advanced peptide synthesis and medicinal chemistry research, where it serves as a key building block for introducing constrained conformational elements. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel therapeutic peptides and peptidomimetics. The specific stereochemistry and protective groups make it an essential reagent for constructing complex molecular architectures with high precision.

Application

• Peptide Synthesis: As a specialized, side-chain protected amino acid building block in Solid-Phase Peptide Synthesis (SPPS) and solution-phase methodologies.
• Medicinal Chemistry & Drug Discovery: For the design and synthesis of novel peptide-based drug candidates, particularly those targeting GPCRs and protein-protein interactions.
• Conformational Studies: To introduce rigid, cyclopropane-based constraints into peptide backbones, enabling the study of structure-activity relationships (SAR).
• Bioconjugation & Probe Development: As a chemically handle-bearing intermediate for creating labeled peptides or affinity probes for biochemical assays.
• Academic Research: In university and institutional labs focused on organic synthesis methodology, peptide science, and chemical biology.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of complex, non-standard peptides for clients.

Basic Information

Product Name	Cyclopropanepropanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Methylamino]-, (αr)-
CAS No.	2243125-98-4
Molecular Formula	C22H23NO4
Molecular Weight	365.42 g/mol
Synonyms	(αR)-α-[[(9H-Fluoren-9-ylmethoxy)carbonyl]methylamino]cyclopropanepropanoic Acid; Fmoc-(R)-3-(2-Cyclopropylethyl)alanine; Fmoc-(R)-Cpa(3-(2-Cyclopropylethyl)); (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-cyclopropylpropanoic Acid; N-Fmoc-N-methyl-L-3-cyclopropylalanine; Fmoc-N-Me-L-3-(2-cyclopropylethyl)Ala-OH; A non-natural Fmoc-protected N-methyl amino acid.
EINECS	Contact for details

Quality Control

Every batch of this high-purity building block is manufactured and tested under strict quality management systems. Specifications typically include identity confirmation by IR and NMR, purity assessment by HPLC (often ≥95% to ≥98%), and control of specific impurities. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all analytical results. Our production adheres to cGMP guidelines where applicable, ensuring consistency and reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For short-term use (days to weeks), storage at 2-8°C in a desiccator is acceptable.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.