Description

(2S)-2-Amino-2-(5-Fluoro-2-Hydroxyphenyl)Acetic Acid Hydrochloride is a high-purity chiral amino acid derivative, serving as a critical building block in advanced pharmaceutical synthesis. Its value lies in providing a structurally defined, fluorinated scaffold essential for modulating the biological activity and metabolic stability of drug candidates. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in areas requiring sophisticated chiral intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in oncology and central nervous system (CNS) drug discovery.
• Peptidomimetics & Bioactive Molecule Synthesis: Used to incorporate fluorinated tyrosine analogues into peptides and pseudopeptides to enhance binding affinity and proteolytic stability.
• Chemical Biology & Proteomics Research: Serves as a precursor for activity-based probes or affinity tags to study enzyme function and protein-protein interactions.
• Asymmetric Catalysis & Ligand Development: Potential use as a precursor for chiral ligands or organocatalysts in enantioselective synthesis.
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical manufacturing.

Basic Information

Product Name	(2S)-2-Amino-2-(5-Fluoro-2-Hydroxyphenyl)Acetic Acid Hydrochloride
CAS No.	2241594-44-3
Molecular Formula	C8H9FNO3 • HCl
Molecular Weight	221.62 (Free base) / 258.08 (HCl salt)
Synonyms	(S)-2-Amino-2-(5-Fluoro-2-hydroxyphenyl)acetic acid hydrochloride; L-5-Fluorotyrosine hydrochloride; (S)-5-Fluorotyrosine HCl; (2S)-2-Azaniumyl-2-(5-fluoro-2-hydroxyphenyl)acetate hydrochloride; 5-Fluoro-L-tyrosine hydrochloride; 5-F-DLPA HCl; F-Tyr-OH • HCl; 5-Fluoro-3-(1-amino-2-carboxyethyl)phenol hydrochloride
EINECS	Contact for details

Quality Control

Our (2S)-2-Amino-2-(5-Fluoro-2-Hydroxyphenyl)Acetic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.