Description

Cyclo(Rgdfk(Azido Peg4)) (CAS No. 2227549-75-7) is a specialized, multifunctional peptide derivative designed for advanced bioconjugation and chemical biology research. This compound matters because it integrates a cyclic peptide backbone with a polyethylene glycol (PEG) spacer and a reactive azido group, enabling precise, site-specific modifications under mild conditions. It is essential for researchers and developers in the pharmaceutical and biotechnology sectors who require high-purity building blocks for creating targeted drug delivery systems, diagnostic probes, and novel biomaterials.

Application

• Bioconjugation & Linker Chemistry: Serves as a key intermediate for "click chemistry" reactions, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAC), to attach peptides, proteins, or other biomolecules to surfaces, nanoparticles, or polymers.
• ADC (Antibody-Drug Conjugate) Development: Used in the synthesis of linker-payload constructs for creating next-generation ADCs, where its PEG moiety improves solubility and pharmacokinetics.
• Proteomics & Biomarker Discovery: Acts as a functionalized handle for labeling and enriching proteins or peptides in mass spectrometry-based studies.
• Materials Science & Surface Functionalization: Enables the modification of biomaterial surfaces (e.g., hydrogels, implants) to introduce bioactive peptide motifs for controlled cell adhesion and tissue engineering.
• Diagnostic Reagent Synthesis: Utilized in the development of fluorescent or radioactive imaging probes for in vitro and in vivo diagnostics.
• Peptide Therapeutics Optimization: Incorporated into peptide-based drug candidates to enhance stability, reduce immunogenicity, and prolong half-life in circulation.

Basic Information

Product Name	Cyclo(Rgdfk(Azido Peg4))
CAS No.	2227549-75-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	c(RGDfK(PEG4-Azide)); Cyclo(Arg-Gly-Asp-D-Phe-Lys(PEG4-azide)); Azido-PEG4-c(RGDfK); cRGDfK(N3-PEG4); Cyclic RGD Peptide Azido PEG4 Conjugate; Azido-PEG4-c(RGDfK); N3-PEG4-cRGDfK; Cyclo(RGDfK(N3-PEG4))
EINECS	Contact for details

Quality Control

Our Cyclo(Rgdfk(Azido Peg4)) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, MS for identity confirmation, and NMR for structural verification, to ensure it meets the high standards required for research and pre-clinical development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.