Description

(3R,4R)-N,1,4-Trimethyl-n-{7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl}Piperidin-3-Amine is a high-purity, advanced pharmaceutical intermediate with a defined stereochemistry. This compound is critical for the research and development of novel small-molecule therapeutics, particularly in oncology and other targeted disease areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of complex active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of targeted kinase inhibitors and other small-molecule drugs.
• Oncology Research: Used in the development of preclinical and clinical candidates for cancer treatment.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Employed in route scouting and scale-up studies for API manufacturing.
• Biochemical Research: Potential use as a tool compound for studying specific biological pathways and enzyme inhibition.
• Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and commercial APIs under GMP guidelines.

Basic Information

Product Name	(3R,4R)-N,1,4-Trimethyl-n-{7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl}Piperidin-3-Amine
CAS No.	2227197-38-6
Molecular Formula	C15H23N5
Molecular Weight	273.38 g/mol
Synonyms	(3R,4R)-N,1,4-Trimethyl-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-amine; (3R,4R)-N,1,4-Trimethyl-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-piperidinamine; 1-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-N,1,4-trimethyl-3-piperidinamine, (3R,4R)-; (3R,4R)-1-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-N,1,4-trimethylpiperidin-3-amine; Pyrrolopyrimidine piperidine amine derivative; Kinase inhibitor intermediate I-001
EINECS	Contact for details

Quality Control

Our (3R,4R)-N,1,4-Trimethyl-n-{7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl}Piperidin-3-Amine is manufactured under strict quality management systems. We provide comprehensive analytical data to support research and development applications. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are available for every batch. Our quality commitment ensures material suitability for advanced pharmaceutical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.