Description

4-Chloropyrimidine-5-Boronic Acid is a high-value organoboron building block and a key intermediate in modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to develop novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with improved efficacy.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology & Probe Development: Employed in the design and synthesis of molecular probes and labeled compounds for diagnostic and research applications.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura couplings to form carbon-carbon bonds efficiently.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CROs/CMOs serving the life sciences industry.

Basic Information

Product Name	4-Chloropyrimidine-5-Boronic Acid
CAS No.	2225169-12-8
Molecular Formula	C4H4BClN2O2
Molecular Weight	158.35 g/mol
Synonyms	(4-Chloropyrimidin-5-yl)boronic acid; 5-Borono-4-chloropyrimidine; 4-Chloro-5-pyrimidineboronic acid; 4-Chloro-5-pyrimidinylboronic acid; 4-Chloro-5-boronopyrimidine; 4-Chloropyrimidine-5-boronic acid pinacol ester (common derivative); 5-(4-Chloropyrimidinyl)boronic acid
EINECS	Contact for details

Quality Control

Every batch of 4-Chloropyrimidine-5-Boronic Acid is produced and tested under stringent quality management protocols to ensure high purity and batch-to-batch consistency. Our products undergo rigorous quality testing, including advanced analytical methods, to ensure compliance with industry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry, and well-ventilated place. This compound is easily oxidized and moisture-sensitive; prolonged exposure to air or moisture should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.