Description

Polymyxin B Nonapeptide Tfa is a synthetic derivative of the polymyxin B antibiotic, specifically engineered for research into bacterial membrane interactions and antimicrobial mechanisms. This high-purity peptide is critical for advancing studies in antibiotic resistance, membrane permeability, and the development of novel therapeutic agents. It is an essential tool for pharmaceutical R&D, academic research, and biotechnology companies focused on infectious disease and peptide-based drug discovery.

Application

• Antimicrobial Research: Used as a key reference compound in studies investigating the mechanism of action of polymyxin antibiotics against Gram-negative bacteria.
• Membrane Permeability Studies: Employed in biophysical research to understand and modulate the outer membrane of bacteria, aiding in the design of potentiator molecules.
• Drug Development: Serves as a starting point or intermediate in the synthesis and development of novel peptide-based antibiotics with improved safety profiles.
• Biochemical Assays: Utilized as a standard or reagent in assays designed to screen for compounds that disrupt bacterial cell membranes.
• Academic & Pharmaceutical R&D: A fundamental research chemical for laboratories exploring new strategies to overcome multidrug-resistant bacterial infections.

Basic Information

Product Name	Polymyxin B Nonapeptide Tfa
CAS No.	2220175-42-6
Molecular Formula	C58H100N16O17 • C2HF3O2
Molecular Weight	~1386.5 g/mol (as TFA salt)
Synonyms	PMBN TFA; Polymyxin B Nonapeptide Trifluoroacetate Salt; Nona-Polymyxin B TFA; Polymyxin B (1-9) TFA; Dab-9 Polymyxin B TFA; Cyclo[[(2S)-2-hydroxy-4-methylpentanoyl]-L-α,γ-diaminobutyryl-[(2S)-2-hydroxy-4-methylpentanoyl]-L-α,γ-diaminobutyryl-D-leucyl-L-α,γ-diaminobutyryl-L-α,γ-diaminobutyryl-D-phenylalanyl-L-leucyl-L-α,γ-diaminobutyryl-L-α,γ-diaminobutyryl-] TFA; Antibiotic Peptide PMBN TFA
EINECS	Contact for details

Quality Control

Our Polymyxin B Nonapeptide Tfa is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters. We support research integrity with products suitable for advanced pharmaceutical and biochemical studies.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.