Description

1-(Tetrahydro-2H-Pyran-2-Yl)-5-(Trifluoromethyl)-1H-Indazol-4-Ol CAS NO 2197061-68-8 is a high-value, multi-functional indazole derivative featuring a tetrahydropyran (THP) protecting group and a trifluoromethyl substituent. This compound is engineered to serve as a critical pharmaceutical intermediate and advanced building block in modern organic synthesis. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecules with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used as a building block for developing new generation herbicides and fungicides, leveraging the bioactivity of the indazole core.
• Chemical Biology Probe Development: Serves as a scaffold for creating molecular probes to study enzyme function and biological pathways.
• Material Science: Potential monomer or additive for specialty polymers where the fluorine content can impart unique surface properties.
• Organic Synthesis Building Block: The THP-protected alcohol and trifluoromethyl group make it a versatile reagent for constructing complex, fluorinated heterocycles.

Basic Information

Product Name	1-(Tetrahydro-2H-Pyran-2-Yl)-5-(Trifluoromethyl)-1H-Indazol-4-Ol
CAS No.	2197061-68-8
Molecular Formula	C13H13F3N2O2
Molecular Weight	286.25 g/mol
Synonyms	4-Hydroxy-1-(tetrahydro-2H-pyran-2-yl)-5-(trifluoromethyl)-1H-indazole; 5-(Trifluoromethyl)-1-(tetrahydropyran-2-yl)-1H-indazol-4-ol; 1-(THP)-5-(trifluoromethyl)-1H-indazol-4-ol; 1-(Oxan-2-yl)-5-(trifluoromethyl)-1H-indazol-4-ol; 2197061-68-8; 1-(Tetrahydro-2H-pyran-2-yl)-5-(trifluoromethyl)-4-indazolol
EINECS	Contact for details

Quality Control

Our production of 1-(Tetrahydro-2H-Pyran-2-Yl)-5-(Trifluoromethyl)-1H-Indazol-4-Ol adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, purity, and impurity profiles. Our quality systems are designed to meet the exacting standards required for GMP-grade intermediates and advanced research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.