Description

L-Phenylalanine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-4-[(2-Propen-1-Yloxy)Carbonyl]- is a sophisticated, orthogonally protected amino acid derivative designed for advanced synthetic applications. This compound is critical for researchers and manufacturers requiring high-precision peptide synthesis, particularly in solid-phase methodologies where selective deprotection is essential. It serves as a key building block for pharmaceutical research, proteomics, and the development of novel bioconjugates, enabling the creation of complex molecules with specific functional handles.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid with an Alloc-protected side chain, it enables sequential, orthogonal deprotection strategies for constructing complex peptides.
• Pharmaceutical Intermediate: A crucial precursor in the research and development of peptide-based therapeutics, including targeted drugs and hormone analogs.
• Bioconjugation and Probe Development: The allyloxycarbonyl (Alloc) protecting group on the side chain allows for selective modification, making it ideal for creating fluorescent probes, affinity labels, or drug-linker systems.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive compounds and optimize peptide leads.
• Academic and Industrial Research: Fundamental tool in biochemistry and organic chemistry laboratories for studying protein structure-function relationships and developing new synthetic methodologies.
• Production of Custom Peptides: Employed by CROs and CDMOs for the reliable and scalable synthesis of bespoke peptide sequences for clients.

Basic Information

Product Name	L-Phenylalanine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-4-[(2-Propen-1-Yloxy)Carbonyl]-
CAS No.	2196198-73-7
Molecular Formula	C28H25NO6
Molecular Weight	471.50 g/mol
Synonyms	Fmoc-Phe(Alloc)-OH; Fmoc-L-Phenylalanine(Alloc)-OH; N-α-Fmoc-N-γ-Alloc-L-phenylalanine; Nα-Fmoc-Nγ-Alloc-L-phenylalanine; Fmoc-Phenylalanine(Alloc); (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[4-(prop-2-en-1-yloxycarbonyl)phenyl]propanoic acid; N-Fmoc-N'-Alloc-L-phenylalanine; Fmoc-Phe(Alloc)
EINECS	Contact for details

Quality Control

Every batch of our Fmoc-Phe(Alloc)-OH is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) detailing purity, specific rotation, and impurity profiles is provided with each shipment to guarantee it meets the exacting standards required for pharmaceutical research and peptide synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation [α]D20	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.