Description

Pyrazolo[1,5-A]Pyrimidine-3-Carbonitrile, 4,5,6,7-Tetrahydro-2-(4-Phenoxyphenyl)-7-(4-Piperidinyl)- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound matters for its role as a critical building block in the synthesis of novel, small-molecule therapeutic agents, particularly in oncology and central nervous system (CNS) research. It is primarily needed by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in developing new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted kinase inhibitors for cancer therapy.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• API Development: Serves as a building block in the multi-step synthesis of potential new chemical entities (NCEs).
• Biochemical Tool Compound: Utilized in vitro and in vivo to study specific biological pathways and validate novel drug targets.
• Custom Synthesis: Supplied for bespoke chemical synthesis projects requiring high-fidelity, complex heterocycles.

Basic Information

Product Name	Pyrazolo[1,5-A]Pyrimidine-3-Carbonitrile, 4,5,6,7-Tetrahydro-2-(4-Phenoxyphenyl)-7-(4-Piperidinyl)-
CAS No.	2190506-57-9
Molecular Formula	C24H23N5O
Molecular Weight	397.48 g/mol
Synonyms	4,5,6,7-Tetrahydro-2-(4-phenoxyphenyl)-7-(4-piperidinyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile; 7-(Piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carbonitrile; Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,5,6,7-tetrahydro-2-(4-phenoxyphenyl)-7-(4-piperidinyl)-; CAS 2190506-57-9; 2190506-57-9
EINECS	Contact for details

Quality Control

Our Pyrazolo[1,5-A]Pyrimidine-3-Carbonitrile intermediate is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding pharmaceutical R&D applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality protocols are designed to meet the stringent requirements of our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.