Description

Pyrido[2,3-D]Pyrimidin-7(8H)-One, 8-[(1R,2R)-2-Hydroxy-2-Methylcyclopentyl]-2-(Methylthio)- is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, offering a sophisticated chiral scaffold for targeted drug discovery. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel therapeutic agents, particularly in oncology and antiviral research.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel, small-molecule drug candidates targeting specific biological pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its complex pyridopyrimidine core.
• Oncology Drug Development: Serves as a precursor for potential kinase inhibitors and other targeted cancer therapies.
• Antiviral Agent Synthesis: Employed in the research and development of new antiviral compounds.
• Biochemical Tool Compound: Used in vitro and in vivo studies to probe enzyme function and cellular signaling mechanisms.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for cGMP-scale production of clinical trial materials and commercial APIs.

Basic Information

Product Name	Pyrido[2,3-D]Pyrimidin-7(8H)-One, 8-[(1R,2R)-2-Hydroxy-2-Methylcyclopentyl]-2-(Methylthio)-
CAS No.	2185860-74-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	8-[(1R,2R)-2-Hydroxy-2-methylcyclopentyl]-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one; (1R,2R)-8-(2-Hydroxy-2-methylcyclopentyl)-2-(methylthio)-7,8-dihydropyrido[2,3-d]pyrimidin-7-one; 2-(Methylthio)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]pyrido[2,3-d]pyrimidin-7(8H)-one; CAS 2185860-74-4
EINECS	Contact for details

Quality Control

Our Pyrido[2,3-D]Pyrimidin-7(8H)-One derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and NMR for structural confirmation. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to ensure compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.