Description

Mal-Amido-Peg9-Nhboc is a heterobifunctional polyethylene glycol (PEG) derivative featuring a maleimide group and a Boc-protected amine, linked by a 9-unit PEG spacer. This compound is a critical reagent for site-specific bioconjugation, enabling the stable attachment of biomolecules, peptides, or drug payloads to targeting vectors. It is essential for researchers and manufacturers in pharmaceutical development, bioconjugation, and advanced material science who require precise and controlled coupling strategies.

Application

• ADC (Antibody-Drug Conjugate) Linker: For the controlled conjugation of cytotoxic drugs to monoclonal antibodies via the maleimide-thiol chemistry.
• PEGylation of Peptides/Proteins: To introduce a hydrophilic PEG spacer and a protected amine handle for further functionalization, improving solubility and pharmacokinetics.
• Surface Functionalization: For modifying nanoparticles, biosensors, or solid supports with a reactive maleimide group for biomolecule immobilization.
• Cross-linking Reagent: In the synthesis of hydrogels or polymer networks requiring specific, orthogonal reactivity.
• Prodrug Synthesis: As a building block for creating cleavable linkers in targeted prodrug systems.
• Diagnostic Reagent Preparation: For conjugating dyes, labels, or contrast agents to antibodies or other targeting molecules.

Basic Information

Product Name	Mal-Amido-Peg9-Nhboc
CAS No.	2182602-20-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Boc-NH-PEG9-Maleimide; Maleimide-PEG9-amine-Boc; Boc-Amino-PEG9-MAL; N-(tert-Butoxycarbonyl)-1-amino-3,6,9,12,15,18,21,24,27-nonaoxa-30-azatriacontan-30-yl)maleimide; 1-[(1,1-Dimethylethoxy)carbonyl]-1-aza-3,6,9,12,15,18,21,24,27-nonaoxa-30-thiatriacontan-30-one 1-oxide (maleimide form); Boc-NH-PEG9-MAL; Heterobifunctional PEG9 linker, Maleimide and Boc-amine
EINECS	Contact for details

Quality Control

Our Mal-Amido-Peg9-Nhboc is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure compliance with research and development standards. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. Use under an inert atmosphere for critical applications.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, chloroform

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.