Description

2-Chloro-5-Iodo-7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine is a high-purity, heterocyclic building block of significant interest in advanced pharmaceutical research and development. This compound matters as a key synthetic intermediate for constructing novel small molecule therapeutics, particularly kinase inhibitors and targeted cancer treatments. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel kinase inhibitors and targeted anticancer agents.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Biochemical Probe Development: Serves as a precursor for creating tool compounds to study specific biological pathways and enzyme functions.
• Process Chemistry & Scale-up: Employed in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services.
• Academic Research: Utilized in university and institutional labs for exploratory research in organic synthesis and chemical biology.

Basic Information

Product Name	2-Chloro-5-Iodo-7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine
CAS No.	2177263-90-8
Molecular Formula	C6H4ClIN4
Molecular Weight	294.48 g/mol
Synonyms	4-Amino-2-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine; 2-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-4-amine; 2-Chloro-5-iodo-4-aminopyrrolo[2,3-d]pyrimidine; 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 2-chloro-5-iodo-; CAS 2177263-90-8
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Iodo-7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.