Description

1-(Pyrimidin-5-Yl)Azetidin-3-Amine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 2173991-64-3. This compound is a critical building block in modern medicinal chemistry, valued for its azetidine and pyrimidine motifs which are prevalent in bioactive molecules. It is primarily utilized by research and development teams in the pharmaceutical and biotechnology sectors for the synthesis of novel drug candidates targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Kinase Inhibitor Synthesis: Used in the construction of small molecule inhibitors targeting various kinases for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology Probes: Employed in the development of tool compounds and probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	1-(Pyrimidin-5-Yl)Azetidin-3-Amine Hydrochloride
CAS No.	2173991-64-3
Molecular Formula	C7H11ClN4
Molecular Weight	186.64 g/mol
Synonyms	3-Amino-1-(5-pyrimidinyl)azetidine hydrochloride; 1-(Pyrimidin-5-yl)azetidin-3-amine HCl; Azetidin-3-amine, 1-(5-pyrimidinyl)-, hydrochloride; 2173991-64-3; 1-(5-Pyrimidinyl)-3-azetidinamine hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(Pyrimidin-5-Yl)Azetidin-3-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, confirming compliance with client specifications and industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.