Description

3-(Benzyloxy)-4-(Trifluoromethyl)Benzaldehyde is a high-purity aromatic aldehyde building block featuring a benzyl-protected phenol and a trifluoromethyl group. This compound is valued for its role as a versatile synthetic intermediate in advanced organic synthesis, where its unique substitution pattern enables the construction of complex molecular architectures. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Liquid Crystal & OLED Material Research: Serves as a building block for creating advanced organic electronic materials and liquid crystal compounds due to its aromatic core and functional groups.
• Cross-Coupling Reactions: The aldehyde functionality makes it a suitable substrate for Palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura couplings, to create biaryl structures.
• Ligand & Catalyst Development: Employed in the design and synthesis of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Fluorine Chemistry Research: An important compound for studying the influence of the trifluoromethyl group on chemical reactivity and physical properties in medicinal chemistry.

Basic Information

Product Name	3-(Benzyloxy)-4-(Trifluoromethyl)Benzaldehyde
CAS No.	2173135-86-7
Molecular Formula	C15H11F3O2
Molecular Weight	280.24 g/mol
Synonyms	4-(Trifluoromethyl)-3-(phenylmethoxy)benzaldehyde; 3-Benzyloxy-4-trifluoromethylbenzaldehyde; Benzaldehyde, 3-(benzyloxy)-4-(trifluoromethyl)-; 4-Trifluoromethyl-3-benzyloxybenzaldehyde; 3-(Benzyloxy)-α,α,α-trifluoro-p-tolualdehyde
EINECS	Contact for details

Quality Control

Every batch of 3-(Benzyloxy)-4-(Trifluoromethyl)Benzaldehyde is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including chromatographic purity analysis and identity confirmation, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term storage or after opening to maintain purity. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.