Description

Fmoc-Ile-Aib-Oh is a specialized, protected dipeptide building block used in solid-phase peptide synthesis (SPPS). This compound is critical for introducing the sterically hindered aminoisobutyric acid (Aib) residue, which is known to induce helical conformations in peptide structures, alongside the hydrophobic isoleucine (Ile). It is essential for researchers and manufacturers developing novel therapeutic peptides, peptidomimetics, and biochemical tools where structural stability and specific folding are required.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the sequential construction of complex peptide chains using Fmoc-chemistry protocols.
• Therapeutic Peptide Development: Used in the research and production of peptide-based pharmaceuticals, including antimicrobial peptides and hormone analogs.
• Peptidomimetic Design: Incorporation of Aib helps create stable, protease-resistant analogs of natural peptides for drug discovery.
• Biochemical Research: Serves as a tool for studying protein folding, helix stabilization, and structure-activity relationships (SAR).
• Material Science: Potential use in creating bio-inspired materials and self-assembling peptide nanostructures.

Basic Information

Product Name	Fmoc-Ile-Aib-Oh
CAS No.	2171139-20-9
Molecular Formula	C24H28N2O5
Molecular Weight	424.49 g/mol
Synonyms	Fmoc-Ile-Aib-OH; Fmoc-L-Isoleucyl-2-aminoisobutyric acid; N-(9-Fluorenylmethoxycarbonyl)-L-isoleucyl-2-aminoisobutyric acid; Fmoc-Ile-Aib; Fmoc-Ile-Aib-acid; (2S)-2-[[(2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-methylpentanoyl]amino]-2-methylpropanoic acid; Fmoc-Ile-α-aminoisobutyric acid; Fmoc-Isoleucine-Aminoisobutyric acid
EINECS	Contact for details

Quality Control

Our Fmoc-Ile-Aib-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) detailing purity, chiral integrity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.