Description

2,3-Difluoro-4-((trimethylsilyl)ethynyl)aniline is a high-value, multi-functional aromatic amine building block featuring both fluorine and a protected alkyne moiety. This compound matters for its unique reactivity profile, enabling the synthesis of complex molecules in a controlled and efficient manner. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in kinase inhibitor and targeted therapy research.
• Agrochemical Synthesis: Used in creating novel herbicides and pesticides where the fluorine atoms and aniline core enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linker in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: The protected alkyne group allows for efficient conjugation via click chemistry, making it valuable for labeling and proteomics studies.
• Organic Synthesis Building Block: Enables Sonogashira coupling and other palladium-catalyzed reactions to construct complex conjugated systems for research and development.

Basic Information

Product Name	2,3-Difluoro-4-((trimethylsilyl)ethynyl)aniline
CAS No.	2149597-51-1
Molecular Formula	C11H13F2NSi
Molecular Weight	225.31 g/mol
Synonyms	4-((Trimethylsilyl)ethynyl)-2,3-difluoroaniline; 2,3-Difluoro-4-[(trimethylsilyl)ethynyl]benzenamine; 2,3-Difluoro-4-(2-trimethylsilylethynyl)aniline; 2,3-Difluoro-4-ethynyl-N-(trimethylsilyl)aniline (incorrect but common search variant); TMS-protected 2,3-difluoro-4-ethynylaniline; Benzenamine, 2,3-difluoro-4-[(trimethylsilyl)ethynyl]-; CAS 2149597-51-1
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-4-((trimethylsilyl)ethynyl)aniline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place (recommended 2-8°C for long-term stability). This material is hygroscopic (moisture-sensitive) and easily oxidized; ensure containers are sealed immediately after use to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	Light yellow to amber solid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.