Description

3-Fluoro-4-((Trimethylsilyl)Ethynyl)Aniline Benzenamine, 3-Fluoro-4-[2-(Trimethylsilyl)Ethynyl]- is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular architecture that combines an aniline core with a fluorine substituent and a protected ethynyl group. This compound is critical for enabling efficient synthetic routes in modern drug discovery, particularly for constructing complex molecules with precise spatial and electronic properties. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and pesticides, where the fluorine atom and ethynyl group enhance biological activity and stability.
• Material Science Research: Serves as a precursor for organic electronic materials, including semiconductors and light-emitting diodes (OLEDs), due to its conjugated system.
• Cross-Coupling Reactions: The trimethylsilyl-protected alkyne moiety makes it an excellent substrate for Sonogashira and other palladium-catalyzed cross-coupling reactions.
• Fluorine Chemistry: Essential for introducing fluorine into complex molecules to modulate their lipophilicity, metabolic stability, and binding affinity.
• Protecting Group Strategy: The TMS-ethynyl group acts as a versatile protecting group that can be selectively deprotected for further functionalization.

Basic Information

Product Name	3-Fluoro-4-((Trimethylsilyl)Ethynyl)Aniline Benzenamine, 3-Fluoro-4-[2-(Trimethylsilyl)Ethynyl]-
CAS No.	2146146-58-7
Molecular Formula	C11H14FNSi
Molecular Weight	207.32 g/mol
Synonyms	3-Fluoro-4-((trimethylsilyl)ethynyl)aniline; 3-Fluoro-4-[2-(trimethylsilyl)ethynyl]benzenamine; 4-Amino-2-fluoro-1-((trimethylsilyl)ethynyl)benzene; 2-Fluoro-4-((trimethylsilyl)ethynyl)aniline; 3-Fluoro-4-(2-trimethylsilylethynyl)aniline; 3-Fluoro-4-(trimethylsilylethynyl)phenylamine; Benzenamine, 3-fluoro-4-[2-(trimethylsilyl)ethynyl]-
EINECS	Contact for details

Quality Control

Our production of 3-Fluoro-4-((Trimethylsilyl)Ethynyl)Aniline adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive R&D and scale-up processes. Each lot undergoes comprehensive analytical characterization, including HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, identity, and impurity profiles. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light). Keep the container tightly sealed under an inert atmosphere to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.