Description

(1R,2S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)Cyclobutanecarboxylic Acid is a specialized, optically pure building block used in advanced organic synthesis. This compound is critical for the development of novel pharmaceuticals and bioactive molecules, particularly in peptide and peptidomimetic research. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in Solid-Phase Peptide Synthesis (SPPS) as a protected amino acid derivative for incorporating the constrained cyclobutane backbone.
• Protease Inhibitor Development: Serves as a core scaffold for designing inhibitors targeting specific enzymes.
• Chemical Biology Research: Employed in the study of protein-protein interactions and structure-activity relationships (SAR).
• Process Chemistry: Used in the scale-up and optimization of synthetic routes for clinical and commercial manufacturing.
• Academic Research: A valuable reagent for methodological development in asymmetric synthesis and medicinal chemistry.

Basic Information

Product Name	(1R,2S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)Cyclobutanecarboxylic Acid
CAS No.	2140262-82-2
Molecular Formula	C20H19NO4
Molecular Weight	337.37 g/mol
Synonyms	Fmoc-(1R,2S)-ACBC-OH; (1R,2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]cyclobutanecarboxylic acid; Fmoc-(1R,2S)-2-aminocyclobutanecarboxylic acid; (1R,2S)-ACBC(Fmoc); Fmoc-(1R,2S)-ACBC; (1R,2S)-2-(Fmoc-amino)cyclobutanecarboxylic acid; trans-Fmoc-2-aminocyclobutanecarboxylic acid (1R,2S)
EINECS	Contact for details

Quality Control

Our (1R,2S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)Cyclobutanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.