Description

n-Fmoc-n-Methyl-3-(2-Naphthyl)-L-Alanine is a protected, non-proteinogenic amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound is a critical building block for the introduction of a sterically hindered, hydrophobic naphthylalanine residue with an N-methylated backbone, enabling the creation of peptides with enhanced metabolic stability, altered conformation, and specific biological activity. It is essential for researchers and manufacturers in pharmaceutical R&D, particularly for developing novel peptide therapeutics, peptidomimetics, and biochemical probes. The product is supplied with a guaranteed high purity to ensure optimal coupling efficiency and final product integrity.

Application

• Pharmaceutical Research & Development: A key intermediate in the synthesis of complex peptide-based drug candidates targeting GPCRs, enzymes, and protein-protein interactions.
• Peptidomimetic Design: Used to incorporate constrained, N-methylated amino acids to improve oral bioavailability, membrane permeability, and proteolytic resistance of lead compounds.
• Solid-Phase Peptide Synthesis (SPPS): Employed in Fmoc-strategy SPPS for the precise assembly of custom peptides requiring the unique properties of 3-(2-naphthyl)-alanine.
• Chemical Biology & Proteomics: Serves as a building block for creating activity-based probes, affinity tags, and labeled peptides for studying biological mechanisms.
• Material Science: Potential use in the synthesis of specialty polymers and self-assembling peptide materials that leverage the aromatic and hydrophobic character of the naphthyl group.

Basic Information

Product Name	n-Fmoc-n-Methyl-3-(2-Naphthyl)-L-Alanine
CAS No.	2138482-09-2
Molecular Formula	C₃₀H₂₇NO₄
Molecular Weight	465.54 g/mol
Synonyms	Fmoc-N-Me-2-Nal-OH; Fmoc-N-Methyl-3-(2-naphthyl)-L-alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-3-(naphthalen-2-yl)-L-alanine; (2S)-3-(Naphthalen-2-yl)-2-[(9H-fluoren-9-ylmethoxy)carbonyl(methyl)amino]propanoic acid; N-α-Fmoc-N-methyl-2-naphthylalanine; Fmoc-N-Me-2-Nal; N-Fmoc-N-methyl-3-(2-naphthyl)alanine
EINECS	Contact for details

Quality Control

Every batch of n-Fmoc-n-Methyl-3-(2-Naphthyl)-L-Alanine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS are available for each lot. Our quality commitment supports compliance in research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.