Description

Z-n-Me-Arg(Pbf)-Oh is a protected arginine derivative, specifically an N-methylated and side-chain protected amino acid building block. This high-purity intermediate is critical for the controlled synthesis of complex peptides and peptidomimetics, ensuring precise molecular architecture. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced peptide chemistry, drug discovery, and the development of therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated, sequential assembly of peptide chains, particularly where N-methylation is required to modulate bioactivity and stability.
• Pharmaceutical Research & Development: Serves as a crucial intermediate in the discovery and development of novel peptide-based drugs, including hormone analogs and enzyme inhibitors.
• Peptidomimetic Design: Used to create non-natural peptide analogs with improved pharmacological properties, such as enhanced metabolic stability and membrane permeability.
• Bioconjugation and Labeling: The protected guanidino group allows for selective deprotection and subsequent conjugation with labels, tags, or other biomolecules.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic Research: A valuable tool for studying peptide structure-activity relationships (SAR) and reaction mechanisms in organic and medicinal chemistry laboratories.

Basic Information

Product Name	Z-n-Me-Arg(Pbf)-Oh
CAS No.	2135655-88-6
Molecular Formula	C27H37N5O7S
Molecular Weight	575.68 g/mol
Synonyms	N-α-Carbobenzoxy-N-ω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-N-δ-methyl-L-arginine; Z-N(Me)-Arg(Pbf)-OH; Z-N-methyl-NG-Pbf-L-arginine; Nα-Z-Nδ-Methyl-Nω-Pbf-L-arginine; Boc-N-Me-Arg(Pbf)-OH (common analog); Fmoc-N-Me-Arg(Pbf)-OH (common analog); N-Methyl-NG-Pbf-L-arginine Z-derivative; Protected N-methylarginine derivative
EINECS	Contact for details

Quality Control

Our Z-n-Me-Arg(Pbf)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients in pre-clinical and development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.