Description

Fmoc-2-Me-Ile-Oh is a protected, non-proteinogenic amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for introducing the sterically hindered 2-methylisoleucine residue into peptide chains, enabling the creation of novel structures with enhanced metabolic stability and biological activity. It is an essential building block for researchers and manufacturers in pharmaceutical development, particularly for the synthesis of peptide therapeutics, peptidomimetics, and investigational new chemical entities.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the automated, stepwise construction of complex peptide sequences.
• Pharmaceutical R&D: Used in the discovery and development of novel peptide-based drugs, including hormone analogs, antimicrobial peptides, and targeted therapeutics.
• Peptidomimetic Design: Incorporation of 2-methylisoleucine alters peptide backbone conformation, aiding in the development of more stable and bioavailable drug candidates.
• Chemical Biology Probes: Serves as a specialized building block for creating labeled or modified peptides used to study protein-protein interactions and enzyme function.
• Process Development & Scale-Up: Supplied in high purity for process chemistry and the cGMP manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Fmoc-2-Me-Ile-Oh
CAS No.	2124196-75-2
Molecular Formula	C21H23NO4
Molecular Weight	353.41 g/mol
Synonyms	Fmoc-2-methylisoleucine; (2S,3S)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-methylpentanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-methyl-L-isoleucine; Fmoc-2-MeIle-OH; Fmoc-(2-Me)Ile-OH; Fmoc-2-methyl-Ile-OH; Nα-Fmoc-2-methylisoleucine
EINECS	Contact for details

Quality Control

Our Fmoc-2-Me-Ile-Oh is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation (IR, NMR). We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.