Description

Benzamide, 2-[[5-Chloro-2-[[2-(2-Fluoroethoxy)-4-[3-(Methylamino)-1-Pyrrolidinyl]Phenyl]Amino]-4-Pyrimidinyl]Amino]-n-Methyl- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant value in modern medicinal chemistry for the research and development of targeted therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates, particularly in oncology and other therapeutic areas.
• Kinase Inhibitor Research: Serves as a core structural motif in the development of potent and selective kinase inhibitors due to its pyrimidine and aniline pharmacophores.
• Medicinal Chemistry & SAR Studies: Used extensively in structure-activity relationship (SAR) studies to optimize drug potency, selectivity, and pharmacokinetic properties.
• Preclinical Development: Employed in the production of compounds for in vitro and in vivo biological testing and toxicology studies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of complex molecules for clinical trials.
• Chemical Reference Standard: Can be used as a high-purity analytical standard for quality control and method development in API manufacturing.

Basic Information

Product Name	Benzamide, 2-[[5-Chloro-2-[[2-(2-Fluoroethoxy)-4-[3-(Methylamino)-1-Pyrrolidinyl]Phenyl]Amino]-4-Pyrimidinyl]Amino]-n-Methyl-
CAS No.	2119738-71-3
Molecular Formula	C25H30ClFN6O2
Molecular Weight	501.00 g/mol
Synonyms	N-Methyl-2-((5-chloro-2-((2-(2-fluoroethoxy)-4-(3-(methylamino)pyrrolidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)benzamide; 2-[[5-Chloro-2-[[2-(2-Fluoroethoxy)-4-[3-(Methylamino)-1-Pyrrolidinyl]Phenyl]Amino]-4-Pyrimidinyl]Amino]-N-Methylbenzamide; UNII-8Q8K7F4S3F; 8Q8K7F4S3F; Benzamide, N-methyl-2-[[5-chloro-2-[[2-(2-fluoroethoxy)-4-[3-(methylamino)-1-pyrrolidinyl]phenyl]amino]-4-pyrimidinyl]amino]-; CAS 2119738-71-3
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization using techniques such as HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles. We support development and cGMP-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider handling under an inert atmosphere such as nitrogen or argon to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.