Description

1-Piperidinepentanoic Acid, γ-Cyano-β-Imino-4-Methyl-3-(Methyl-7H-Pyrrolo[2,3-D]Pyrimidin-4-Ylamino)-δ-Oxo-, Ethyl Ester, (3R,4R)- is a sophisticated, stereochemically defined heterocyclic building block of significant interest in advanced pharmaceutical research and development. This compound matters as a key synthetic intermediate, particularly for the construction of complex molecules targeting specific biological pathways, where its precise stereochemistry is critical for activity. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries working on novel therapeutics, especially kinase inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the multi-step synthesis of potential active pharmaceutical ingredients (APIs), particularly for oncology and immunology targets.
• Kinase Inhibitor Research: Used in the research and development of novel kinase inhibitors, leveraging its pyrrolopyrimidine core structure, a privileged scaffold in this drug class.
• Medicinal Chemistry & SAR Studies: Enables structure-activity relationship (SAR) studies to optimize the potency, selectivity, and pharmacokinetic properties of lead drug candidates.
• Process Chemistry & Scale-Up: Employed in route scouting and process optimization for the efficient and scalable production of development compounds.
• Bioconjugation & Probe Development: Potential use in creating chemical probes or bioconjugates for biochemical and cellular assay development due to its functionalized structure.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) and research institutions for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	1-Piperidinepentanoic Acid, γ-Cyano-β-Imino-4-Methyl-3-(Methyl-7H-Pyrrolo[2,3-D]Pyrimidin-4-Ylamino)-δ-Oxo-, Ethyl Ester, (3R,4R)-
CAS No.	2102039-99-4
Molecular Formula	C22H29N7O3
Molecular Weight	439.52 g/mol
Synonyms	(3R,4R)-Ethyl 3-cyano-2-imino-4-methyl-3-[(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-5-oxo-1-(piperidin-1-yl)pentanoate; (3R,4R)-Ethyl γ-cyano-β-imino-4-methyl-3-((4-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-δ-oxo-1-(piperidin-1-yl)pentanoate; UNII-Contact for details; 2102039-99-4; Advanced Pyrrolopyrimidine Intermediate; Chiral Piperidine-Pyrrolopyrimidine Conjugate
EINECS	Contact for details

Quality Control

Our 1-Piperidinepentanoic Acid, γ-Cyano-β-Imino-4-Methyl-3-(Methyl-7H-Pyrrolo[2,3-D]Pyrimidin-4-Ylamino)-δ-Oxo-, Ethyl Ester, (3R,4R)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical R&D. All products undergo rigorous analytical testing including HPLC, NMR, and chiral purity analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Keep container tightly sealed in a cool, dry, and well-ventilated place. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (3R,4R)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.