Description

Fmoc-n-Amido-Peg10-Acid CAS NO 2101563-45-3 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a cleavable Fmoc-protected amine at one terminus and a carboxylic acid group at the other. This compound is engineered to serve as a versatile spacer and linker in bioconjugation and peptide synthesis, offering enhanced solubility and reduced immunogenicity. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing advanced drug delivery systems, peptide therapeutics, and diagnostic reagents.

Application

• Bioconjugation Linker: For coupling peptides, proteins, or antibodies to surfaces, nanoparticles, or other biomolecules to create targeted therapeutics and diagnostics.
• Solid-Phase Peptide Synthesis (SPPS): Acts as a hydrophilic, flexible spacer to incorporate PEG chains into synthetic peptides, improving their pharmacokinetic properties.
• ADC (Antibody-Drug Conjugate) Development: Used in the construction of linkers between cytotoxic payloads and monoclonal antibodies, leveraging its cleavable Fmoc-amine for controlled drug release.
• Hydrogel and Biomaterial Fabrication: Serves as a cross-linking agent or functional modifier to create biocompatible scaffolds for tissue engineering and controlled release applications.
• Diagnostic Probe Synthesis: Facilitates the attachment of reporter molecules (e.g., fluorophores, chelators) to targeting ligands for imaging and detection assays.
• Solubility Enhancer: Incorporation into drug molecules to significantly improve aqueous solubility and bioavailability.

Basic Information

Product Name	Fmoc-n-Amido-Peg10-Acid
CAS No.	2101563-45-3
Molecular Formula	C58H95N3O26
Molecular Weight	~1242.4 g/mol
Synonyms	Fmoc-NH-PEG10-COOH; 22-Aza-3,6,9,12,15,18,21,24,27,30-decaoxadotriacontane-1,32-dioic acid, 22-[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1-(1,1-dimethylethyl) 32-ethyl ester; Fmoc-Amino-PEG10-acid; N-α-Fmoc-11-amino-3,6,9-trioxaundecanoic acid (PEG10 extended); Fmoc-15-amino-4,7,10,13-tetraoxapentadecanoic acid; Boc-NH-PEG10-COOH (related protected form); Heterobifunctional PEG10 linker; Fmoc-PEG10-acid.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical applications. Each batch is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C to -10°C under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white waxy solid or powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.