Description

6-(4-Acetylpiperazin-1-Yl)Pyrimidine-2,4(1H,3H)-Dione is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic structure combining pyrimidine and piperazine moieties. This compound is critical for medicinal chemistry research and development, offering a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in areas such as kinase inhibition and targeted oncology treatments.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of complex drug candidates and novel chemical entities (NCEs).
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Development: Its structural features make it a valuable starting material for synthesizing potential kinase inhibitors, a major class of targeted cancer therapies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of specialized APIs under cGMP conditions.
• Biochemical Research: May be used in biochemical assays and as a tool compound for probing specific biological pathways and enzyme functions.
• Academic Research: Employed in university and institutional laboratories for advanced organic synthesis projects and the development of new synthetic methodologies.

Basic Information

Product Name	6-(4-Acetylpiperazin-1-Yl)Pyrimidine-2,4(1H,3H)-Dione
CAS No.	2098095-17-9
Molecular Formula	C10H14N4O3
Molecular Weight	238.25 g/mol
Synonyms	6-(4-Acetyl-1-piperazinyl)-2,4(1H,3H)-pyrimidinedione; 6-(4-Acetylpiperazin-1-yl)pyrimidine-2,4(1H,3H)-dione; 6-(4-Acetylpiperazin-1-yl)-1H-pyrimidine-2,4-dione; 6-(4-Acetylpiperazin-1-yl)uracil; 1-(4-Acetylpiperazin-1-yl)-6-hydroxypyrimidine-2,4-dione; 2098095-17-9; AKOS026713004; ZINC000103048532
EINECS	Contact for details

Quality Control

Our 6-(4-Acetylpiperazin-1-Yl)Pyrimidine-2,4(1H,3H)-Dione is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques. We adhere to relevant industry guidelines to support our customers' regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.