Description

1-(Pyrimidin-4-Yl)Azetidin-3-Amine Dihydrochloride is a high-purity, heterocyclic organic building block of significant interest in advanced pharmaceutical research and development. Its core value lies in its utility as a key synthetic intermediate for constructing novel small molecule drug candidates, particularly in kinase inhibitor programs. This compound is essential for medicinal chemists and process development scientists working in pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality chemical intermediates to accelerate their discovery pipelines.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for targeted cancer therapies.
• Kinase Inhibitor Development: Serves as a core scaffold or a key fragment in the design and synthesis of potent and selective kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to explore new chemical space.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the efficient, scalable production of candidate drugs.
• Bioconjugation & Probe Synthesis: The amine functionality allows for derivatization to create chemical probes for biological target identification and validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug discovery and development projects.

Basic Information

Product Name	1-(Pyrimidin-4-Yl)Azetidin-3-Amine Dihydrochloride
CAS No.	2098025-74-0
Molecular Formula	C7H12Cl2N4
Molecular Weight	223.11 g/mol
Synonyms	3-Amino-1-(4-pyrimidinyl)azetidine dihydrochloride; 1-(Pyrimidin-4-yl)azetidin-3-amine dihydrochloride; Azetidin-3-amine, 1-(4-pyrimidinyl)-, dihydrochloride; 4-(3-Aminoazetidin-1-yl)pyrimidine dihydrochloride; 1-(4-Pyrimidinyl)-3-azetidinamine dihydrochloride; 2098025-74-0; 1-Pyrimidin-4-yl-azetidin-3-ylamine dihydrochloride
EINECS	Contact for details

Quality Control

Our 1-(Pyrimidin-4-Yl)Azetidin-3-Amine Dihydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.