Description

Fmoc-Ile-(Dmb)Gly-Oh is a specialized, orthogonally protected dipeptide building block used in solid-phase peptide synthesis (SPPS). This compound is critical for enabling the precise, sequential assembly of complex peptides and peptidomimetics, particularly in the synthesis of challenging sequences. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the Fmoc/t-Bu strategy, facilitating the controlled elongation of peptide chains.
• Pharmaceutical Research & Development: For the synthesis of novel peptide-based drug candidates, including hormone analogs, antimicrobial peptides, and targeted therapeutics.
• Peptidomimetic Design: Enabling the incorporation of non-natural amino acid motifs to enhance metabolic stability, bioavailability, and binding affinity of peptide leads.
• Combinatorial Chemistry Libraries: Serving as a high-purity component in the generation of diverse peptide libraries for high-throughput screening.
• Bioconjugation and Probe Development: Used in the preparation of peptide tags, fluorescent probes, and other bioconjugates for diagnostic and research applications.
• Academic Research: A fundamental reagent in university and institutional labs studying protein-protein interactions, enzyme substrates, and structural biology.

Basic Information

Product Name	Fmoc-Ile-(Dmb)Gly-Oh
CAS No.	2095208-17-4
Molecular Formula	C₃₃H₃₆N₂O₇
Molecular Weight	584.65 g/mol
Synonyms	Fmoc-Ile-(Dmb)Gly-OH; Fmoc-Ile-(2,4-dimethoxybenzyl)Gly-OH; N-(9-Fluorenylmethoxycarbonyl)-L-isoleucyl-N-(2,4-dimethoxybenzyl)glycine; Fmoc-L-Ile-(Dmb)Gly-OH; Fmoc-Ile-Dmb-Gly-OH; (2S)-2-[(2-{[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-methylpentanoyl]amino]-2-(2,4-dimethoxybenzyl)acetic acid; Fmoc-Ile-(Dmb)-Gly-OH; Fmoc-Ile-(Dmb)Gly
EINECS	Contact for details

Quality Control

Our Fmoc-Ile-(Dmb)Gly-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive peptide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can support development under cGMP guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.