Description

3,5-Difluoro-2-(Trifluoromethyl)-Benzaldehyde is a high-value fluorinated aromatic aldehyde building block, essential for introducing specific steric and electronic properties into advanced molecular architectures. Its unique structure, featuring both difluoro and trifluoromethyl substituents, makes it a critical intermediate for synthesizing compounds with enhanced metabolic stability, lipophilicity, and binding affinity. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the discovery and scale-up of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms improve biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: A versatile reagent in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• Fluorine Chemistry: Employed in further functionalization reactions, such as nucleophilic aromatic substitution or reductive amination, to create complex fluorinated molecules.

Basic Information

Product Name	3,5-Difluoro-2-(Trifluoromethyl)-Benzaldehyde
CAS No.	2090130-84-8
Molecular Formula	C8H3F5O
Molecular Weight	210.10 g/mol
Synonyms	2-(Trifluoromethyl)-3,5-difluorobenzaldehyde; 3,5-Difluoro-2-trifluoromethylbenzaldehyde; Benzaldehyde, 3,5-difluoro-2-(trifluoromethyl)-; 3,5-Difluoro-alpha,alpha,α-trifluoro-o-tolualdehyde
EINECS	Contact for details

Quality Control

Every batch of 3,5-Difluoro-2-(Trifluoromethyl)-Benzaldehyde is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the exacting standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials such as strong oxidizing agents, strong bases, and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.