Description

5-Bromo-4-Chloro-2-(Trifluoromethyl)Quinazoline is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound is engineered to serve as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique halogen and trifluoromethyl substitution pattern enables precise molecular modifications. It is essential for researchers and process chemists in pharmaceutical R&D, agrochemical discovery, and advanced material science seeking to introduce specific pharmacophores or enhance compound properties like metabolic stability and lipophilicity.

Application

This versatile quinazoline derivative is a key synthetic intermediate with applications across several high-tech industries:

• Pharmaceutical Intermediate: Serves as a core scaffold for the synthesis of kinase inhibitors, anticancer agents, and other small-molecule therapeutics.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the quinazoline core.
• Material Science Precursor: Acts as a building block for organic electronic materials, such as OLEDs and semiconductors, due to its electron-deficient aromatic system.
• Chemical Biology & Proteomics: Employed in the design of activity-based probes and molecular tags for studying enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs producing complex molecules for clients.

Basic Information

Product Name	5-Bromo-4-Chloro-2-(Trifluoromethyl)Quinazoline
CAS No.	2089311-03-3
Molecular Formula	C9H3BrClF3N2
Molecular Weight	311.48 g/mol
Synonyms	5-Bromo-4-chloro-2-(trifluoromethyl)quinazoline; 2-(Trifluoromethyl)-5-bromo-4-chloroquinazoline; Quinazoline, 5-bromo-4-chloro-2-(trifluoromethyl)-; 2089311-03-3; 5-Bromo-4-chloro-2-trifluoromethylquinazoline; 4-Chloro-5-bromo-2-(trifluoromethyl)quinazoline
EINECS	Contact for details

Quality Control

Our 5-Bromo-4-Chloro-2-(Trifluoromethyl)Quinazoline is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our commitment to quality supports compliance with cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and stored in a desiccated environment away from direct light to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.