Description

3,5-Difluoro-4-Formylphenylboronic Acid Pinacol Ester is a high-value, multifunctional boronic ester building block essential for modern synthetic chemistry. Its core value lies in the strategic combination of a protected boronic acid group and a reactive aldehyde functionality, enabling efficient cross-coupling and subsequent derivatization in a single molecule. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex fluorinated aromatic scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel, fluorinated active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used to create fluorinated analogs of herbicides, fungicides, and insecticides, where fluorine atoms can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Development: Serves as a building block for fluorinated aromatic cores in electronic and optoelectronic materials, improving performance characteristics.
• Polymer & Resin Modification: Incorporated into specialty polymers to impart specific thermal, chemical, or surface properties via the reactive formyl group.
• Chemical Biology & Probe Design: Utilized in the synthesis of fluorinated molecular probes and tags for imaging and diagnostic applications.
• Academic & Contract Research: A versatile reagent for methodological development and exploring new synthetic pathways in fluoroorganic chemistry.

Basic Information

Product Name	3,5-Difluoro-4-Formylphenylboronic Acid Pinacol Ester
CAS No.	2088247-40-7
Molecular Formula	C₁₄H₁₇BF₂O₃
Molecular Weight	282.09 g/mol
Synonyms	(4-Formyl-3,5-difluorophenyl)boronic acid pinacol ester; 2-(4-Formyl-3,5-difluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane; 3,5-Difluoro-4-formylbenzeneboronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-(3,5-difluoro-4-formylphenyl)-1,3,2-dioxaborolane; Pinacol (3,5-difluoro-4-formylphenyl)boronate; Boronic acid, B-(4-formyl-3,5-difluorophenyl)-, 1,1-dimethylethyl ester (9CI); 2088247-40-7
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-Formylphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to consistent quality supports your research and scale-up processes with reliable, batch-to-batch reproducibility.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can compromise product stability and reactivity. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.