Description

tert-Butyl 2-(4,6-Dichloropyrimidin-2-Yl)Pyrrolidine-1-Carboxylate CAS NO 2080361-24-4 is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyrrolidine-pyrimidine core structure. This compound is of critical importance for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in kinase inhibitor research and development. It is primarily needed by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and agrochemical innovators seeking to develop novel, high-value compounds.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of kinase inhibitors and other targeted therapeutics.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, leveraging its heterocyclic structure.
• Chemical Biology Probes: Serves as a scaffold for creating molecular probes to study enzyme function and biological pathways.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial manufacturing of APIs.
• Academic & Institutional Research: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies.
• Custom Synthesis: A starting material for the contract synthesis of bespoke, complex organic molecules.

Basic Information

Product Name	tert-Butyl 2-(4,6-Dichloropyrimidin-2-Yl)Pyrrolidine-1-Carboxylate
CAS No.	2080361-24-4
Molecular Formula	C13H17Cl2N3O2
Molecular Weight	318.20 g/mol
Synonyms	1-Boc-2-(4,6-dichloropyrimidin-2-yl)pyrrolidine; tert-Butyl 2-(4,6-dichloro-2-pyrimidinyl)-1-pyrrolidinecarboxylate; 2-(4,6-Dichloropyrimidin-2-yl)-1-(tert-butoxycarbonyl)pyrrolidine; 1-(tert-Butoxycarbonyl)-2-(4,6-dichloropyrimidin-2-yl)pyrrolidine; 2080361-24-4; Pyrrolidine-1-carboxylic acid, 2-(4,6-dichloro-2-pyrimidinyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(4,6-Dichloropyrimidin-2-Yl)Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring the material meets the stringent requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator for long-term storage to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.