Description

Fmoc-α-Me-Homophe-Oh is a high-purity, non-natural amino acid derivative protected with a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise incorporation of modified amino acid residues to enhance peptide stability and biological activity. It is essential for researchers and manufacturers in pharmaceutical R&D, biotechnology, and academic research focused on developing novel peptide therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated, sequential assembly of custom peptides.
• Pharmaceutical Research: Used in the discovery and development of peptide-based drugs, including hormone analogs and enzyme inhibitors.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides for imaging, diagnostics, and target identification.
• Structure-Activity Relationship (SAR) Studies: Incorporates α-methyl homophenylalanine to study the effects of backbone and side-chain modifications on peptide function and stability.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse peptide libraries for high-throughput screening.
• Academic & Institutional Research: Fundamental research tool in biochemistry, medicinal chemistry, and chemical biology laboratories.

Basic Information

Product Name	Fmoc-α-Me-Homophe-Oh
CAS No.	2079062-43-2
Molecular Formula	C26H25NO4
Molecular Weight	415.48 g/mol
Synonyms	Fmoc-α-methyl-homophenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-α-methyl-L-homophenylalanine; Fmoc-α-Me-Hph-OH; Fmoc-α-methyl-2-amino-4-phenylbutanoic acid; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-methyl-4-phenylbutanoic acid; N-Fmoc-α-methyl-L-homophenylalanine; Fmoc-α-Me-HomoPhe-OH
EINECS	Contact for details

Quality Control

Our Fmoc-α-Me-Homophe-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.