Description

N4-Boc-5-Fluorocytosin-1-Yl-Acetic Acid Benzyl Ester is a high-purity, protected nucleoside derivative essential for advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate, enabling the precise construction of modified oligonucleotides and nucleoside analogs. It is primarily required by research institutions and pharmaceutical companies engaged in the development of novel antiviral agents, anticancer therapeutics, and diagnostic probes.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated cytidine analogs with potential antiviral and anticancer activity.
• Oligonucleotide Synthesis: Used in the preparation of modified DNA/RNA strands for antisense therapy, siRNA, and diagnostic applications.
• Prodrug Development: Serves as a protected precursor in the design of nucleoside prodrugs to enhance bioavailability and targeting.
• Medicinal Chemistry Research: A versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Bioconjugation: The reactive ester group facilitates conjugation to polymers, peptides, or other biomolecules for targeted delivery systems.
• Chemical Biology Probes: Enables the creation of labeled nucleosides for studying cellular processes and enzyme mechanisms.

Basic Information

Item	Details
Product Name	N4-Boc-5-Fluorocytosin-1-Yl-Acetic Acid Benzyl Ester
CAS No.	2072152-20-4
Molecular Formula	C18H20FN3O5
Molecular Weight	377.37 g/mol
Synonyms	1-[(Benzyloxy)carbonylmethyl]-5-fluoro-N4-(tert-butoxycarbonyl)cytosine; 5-Fluoro-N4-Boc-cytosin-1-yl-acetic Acid Benzyl Ester; Benzyl 2-((5-fluoro-4-((tert-butoxycarbonyl)amino)-2-oxopyrimidin-1(2H)-yl)acetate; N4-(tert-Butoxycarbonyl)-5-fluorocytosin-1-yl-acetic Acid Benzyl Ester; 1-Carboxymethyl-5-fluoro-N4-Boc-cytosine Benzyl Ester; 5-Fluoro-1-(2-(benzyloxy)-2-oxoethyl)-N-(tert-butoxycarbonyl)cytosine; N-Boc-5-fluorocytosin-1-yl-acetic acid benzyl ester
EINECS	Contact for details

Quality Control

Our N4-Boc-5-Fluorocytosin-1-Yl-Acetic Acid Benzyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.5%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.