Description

Pglu-Pro-Arg-Mna (Monoacetate) is a synthetic peptide derivative, specifically a fluorogenic substrate, designed for high-sensitivity enzymatic assays. This compound is critical for researchers and quality control laboratories requiring precise measurement of specific protease activity. It is primarily utilized in the pharmaceutical, diagnostic, and life science research sectors for developing and validating analytical methods.

Application

• Protease Activity Assays: As a selective fluorogenic substrate for measuring the activity of thrombin and other related serine proteases in biochemical research.
• Diagnostic Kit Development: A key component in the formulation of in-vitro diagnostic (IVD) kits for hemostasis and coagulation testing.
• Pharmaceutical R&D: Used in drug discovery and development for screening and characterizing protease inhibitors.
• Quality Control (QC) Testing: Employed in biopharmaceutical manufacturing QC to monitor and validate the purity and activity of enzyme-based products.
• Clinical Research: Applied in studies investigating blood coagulation pathways, thrombosis, and related disorders.
• Enzyme Kinetic Studies: Utilized to determine kinetic parameters (Km, Vmax) of target proteases due to its specific cleavage and fluorescent signal generation.

Basic Information

Product Name	Pglu-Pro-Arg-Mna (Monoacetate)
CAS No.	2070009-26-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Pyrrolidonecarboxylic Acid-Pro-Arg-MNA Monoacetate; L-Pyroglutamyl-L-prolyl-L-arginine 4-methylcoumaryl-7-amide Monoacetate; Thrombin Substrate III, Fluorogenic; Boc-Glu-Pro-Arg-MCA Analog; Fluorogenic Thrombin Substrate; Pglu-Pro-Arg-AMC related substrate; 7-Amino-4-methylcoumarin (AMC) based peptide substrate.
EINECS	Contact for details

Quality Control

Our Pglu-Pro-Arg-Mna (Monoacetate) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and diagnostic applications. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.