Description

T-Boc-Aminooxy-Peg4-Ch2Co2-T-Bu is a specialized bifunctional polyethylene glycol (PEG) linker featuring orthogonal tert-butyloxycarbonyl (Boc) and tert-butyl ester protecting groups. This compound is engineered to facilitate the controlled conjugation of aminooxy-containing molecules to carboxylic acids, enabling precise bioconjugation and chemical biology applications. It is a critical reagent for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing antibody-drug conjugates (ADCs), peptide therapeutics, and advanced diagnostic probes. The product is supplied as a high-purity chemical building block to ensure reliable and reproducible results in sensitive synthetic workflows.

Application

• Bioconjugation Reagent: A key building block for the site-specific conjugation of aminooxy-functionalized payloads (e.g., drugs, dyes, toxins) to carboxylic acid groups on proteins, antibodies, or peptides.
• Antibody-Drug Conjugate (ADC) Development: Used in the synthesis of linker-payload constructs for ADC manufacturing, enabling controlled drug attachment and release.
• PEGylation Chemistry: Serves as a heterobifunctional PEG spacer to improve the solubility, stability, and pharmacokinetic properties of therapeutic biomolecules.
• Chemical Biology Probes: Facilitates the creation of labeled biomolecules for imaging, diagnostic assays, and target identification studies.
• Solid-Phase Peptide Synthesis (SPPS): Employed as a protected linker for the stepwise assembly of complex peptide-PEG conjugates.
• Material Science & Surface Functionalization: Used to modify surfaces or nanoparticles with bioactive ligands for targeted delivery systems.

Basic Information

Item	Details
Product Name	T-Boc-Aminooxy-Peg4-Ch2Co2-T-Bu
CAS No.	2062663-63-0
Molecular Formula	C24H46N2O11
Molecular Weight	538.64 g/mol
Synonyms	1-Boc-aminooxy-3,6,9,12-tetraoxapentadecan-15-oic acid tert-butyl ester; 15-[(1,1-Dimethylethoxy)carbonyl]aminooxy-4,7,10,13-tetraoxapentadecanoic acid 1,1-dimethylethyl ester; Boc-NH-O-PEG4-CH2COOtBu; tert-Butyl 17-((tert-butoxycarbonyl)amino)-4,7,10,13-tetraoxa-16-azaheptadecanoate; Aminooxy-PEG4-t-butyl ester Boc protected; T-Boc-Aminooxy-PEG4-acid-T-Bu ester; Boc-Aminooxy-PEG4-C2-acid-t-Butyl ester
EINECS	Contact for details

Quality Control

Our T-Boc-Aminooxy-Peg4-Ch2Co2-T-Bu is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We support compliance with cGMP and ISO 9001 guidelines for critical raw materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress. Store in a cool, dry, well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.