Description

Benzenepentanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-4-Iodo-, (αs)- is a sophisticated, non-natural amino acid derivative featuring a fluorenylmethyloxycarbonyl (Fmoc) protecting group and an iodine substituent. This compound matters as a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled introduction of iodinated aromatic side chains for the development of novel peptides with tailored properties. Pharmaceutical researchers and fine chemical manufacturers need this high-purity intermediate for creating peptide-based drug candidates, diagnostic probes, and advanced materials where precise structural modification is essential.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key Fmoc-protected iodinated amino acid monomer for the automated synthesis of complex peptides.
• Pharmaceutical Research & Development: Used in the discovery and development of novel peptide therapeutics, including hormone analogs and receptor-targeting agents.
• Chemical Biology & Bioconjugation: The iodine atom provides a versatile handle for further functionalization via cross-coupling reactions (e.g., Suzuki, Sonogashira) for labeling or creating peptide-drug conjugates.
• Material Science: Incorporated into engineered peptides for creating functional biomaterials and nanostructures.
• Academic Research: A valuable reagent for studying peptide structure-activity relationships and developing new synthetic methodologies.
• Radiopharmaceutical Precursor: The iodine moiety can be a precursor for radioiodination, useful in developing diagnostic imaging agents.

Basic Information

Product Name	Benzenepentanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-4-Iodo-, (αs)-
CAS No.	2055144-89-1
Molecular Formula	C26H24INO4
Molecular Weight	541.38 g/mol
Synonyms	Fmoc-4-Iodo-D-homophenylalanine; Fmoc-4-Iodo-D-Hph-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4-(4-iodophenyl)butanoic acid; Fmoc-D-4-Iodohomophenylalanine; 4-Iodo-D-homophenylalanine, N-Fmoc derivative; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-iodo-D-homophenylalanine; Fmoc-Hph(4-I)-OH; BRN 2055144-89-1
EINECS	Contact for details

Quality Control

Our Benzenepentanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-4-Iodo-, (αs)- is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive research and production applications. All products undergo rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.