Description

n-(Amino-Peg3)-n-Bis(Peg3-Acid) Hcl Salt is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative, specifically engineered as a versatile linker for bioconjugation and advanced materials science. Its core value lies in providing a controlled, water-soluble spacer arm with distinct reactive termini—an amine and two carboxylic acids—enabling the precise cross-linking of biomolecules, polymers, and surfaces. This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and nanotechnology, where reliable and reproducible conjugation chemistry is critical.

Application

• Bioconjugation and ADC Development: As a heterobifunctional cross-linker for attaching antibodies, proteins, peptides, or small molecule drugs, particularly in the synthesis of Antibody-Drug Conjugates (ADCs).
• PEGylation Reagent: For modifying therapeutic proteins, peptides, and nanoparticles to enhance solubility, stability, and circulation half-life.
• Surface Functionalization: For creating amine- or carboxyl-terminated self-assembled monolayers (SAMs) on gold, silica, or polymer surfaces for biosensor and microarray applications.
• Dendrimer and Polymer Synthesis: As a building block for constructing complex, branched polymeric architectures with defined chemical functionality.
• Hydrogel Formation: Acting as a cross-linking agent in the creation of biocompatible hydrogels for drug delivery and tissue engineering.
• Diagnostic Reagent Formulation: Used in the development of diagnostic assays and imaging probes that require stable, water-soluble linkers.

Basic Information

Product Name	n-(Amino-Peg3)-n-Bis(Peg3-Acid) Hcl Salt
CAS No.	2055042-59-4
Molecular Formula	C23H46ClN2O12
Molecular Weight	577.07 g/mol
Synonyms	1-Amino-3,6,9-trioxaundecane-11-carboxylic acid, 11,11'-[iminobis(2,1-ethanediyloxy-3,1-propanediyl)]bis-, hydrochloride; 2,2'-(2,2'-(2-(2-(2-Aminoethoxy)ethoxy)ethylazanediyl)bis(ethane-2,1-diyl))bis(oxy)diacetic acid hydrochloride; Amino-PEG3-tris(carboxyethyl)amine hydrochloride; Heterobifunctional PEG crosslinker, NH2-PEG3-tris(COOH); Tris-PEG3-acid-amine HCl salt; 15-Aza-4,7,10,13-tetraoxa-1,16-heptadecanedioic acid, 17-amino-, hydrochloride
EINECS	Contact for details

Quality Control

Our n-(Amino-Peg3)-n-Bis(Peg3-Acid) Hcl Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and titration for active group quantification, to ensure it meets the high standards required for research and cGMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Amine Content (Titration)	≥ 90% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.