Description

Azido-Peg1-Val-Cit-Pab-Oh is a specialized, heterobifunctional linker molecule designed for the controlled conjugation of payloads in advanced bioconjugation strategies. Its core value lies in its precise chemical architecture, which incorporates an azide group for click chemistry and a protease-cleavable Valine-Citrulline-PAB sequence, enabling the construction of targeted drug delivery systems. This compound is essential for researchers and manufacturers in the fields of antibody-drug conjugate (ADC) development, targeted therapeutics, and advanced bioconjugation.

Application

• Critical component in the synthesis of antibody-drug conjugates (ADCs) and other targeted biopharmaceuticals.
• Used as a protease-cleavable linker for attaching cytotoxic payloads to monoclonal antibodies or targeting ligands.
• Enables site-specific conjugation via copper-free click chemistry reactions with alkyne-functionalized molecules.
• Facilitates the development of novel prodrugs and stimuli-responsive drug delivery platforms.
• Applied in bioconjugation research for creating stable, defined protein-payload constructs.
• Supports the manufacturing of next-generation oncology therapeutics with improved efficacy and safety profiles.
• Utilized in the development of diagnostic imaging agents and theranostics.

Basic Information

Product Name	Azido-Peg1-Val-Cit-Pab-Oh
CAS No.	2055041-40-0
Molecular Formula	C24H36N8O8
Molecular Weight	564.6 g/mol
Synonyms	Azido-PEG1-Val-Cit-PAB-OH; N3-PEG1-VC-PAB-OH; Azido-PEG1-valine-citrulline-PAB-OH; ADC Linker Azido-PEG1-VC-PAB; 2-Azidoethyl (2S)-2-[[(2S)-2-[[(2S)-5-amino-1-[[4-[[(2S)-1-hydroxy-3-oxo-1-phenylpropan-2-yl]amino]-4-oxobutanoyl]amino]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]acetate; Valine-Citrulline-PAB-Azido-PEG1 Linker; Protease-Cleavable ADC Linker with Azide
EINECS	Contact for details

Quality Control

Our Azido-Peg1-Val-Cit-Pab-Oh is manufactured under strict quality management systems to ensure the high purity and consistency required for pharmaceutical research and development. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all specifications and test results to support your regulatory filings and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep the primary container in a sealed secondary container with an appropriate desiccant. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.