Description

Mal-Peg4-Val-Cit-Pab-OH is a high-purity, heterobifunctional cleavable linker compound designed for advanced bioconjugation and drug delivery applications. Its core value lies in its precise structure, which incorporates a maleimide group for thiol conjugation, a protease-cleavable Valine-Citrulline-PAB sequence, and a terminal hydroxyl for further functionalization, enabling the construction of stable, targeted therapeutic agents. This compound is essential for researchers and manufacturers in the fields of antibody-drug conjugate (ADC) development, targeted prodrug synthesis, and advanced bioconjugate chemistry.

Application

• Antibody-Drug Conjugate (ADC) Linker: A critical component for constructing ADCs, connecting cytotoxic payloads to monoclonal antibodies via a stable, protease-cleavable bridge.
• Targeted Prodrug Synthesis: Used to create prodrugs that remain inert until cleaved by specific enzymes (e.g., cathepsin B) at the tumor site, enhancing therapeutic specificity and reducing systemic toxicity.
• Bioconjugation and Protein Labeling: Facilitates the site-specific attachment of drugs, dyes, or other molecules to proteins, peptides, or nanoparticles bearing free thiol groups.
• Polymer-Drug Conjugate Development: Serves as a key linker in the design of polymer-based drug delivery systems for controlled release.
• Research and Development: A vital tool in pharmaceutical R&D for exploring new targeted therapy modalities and drug delivery mechanisms.
• Diagnostic Agent Conjugation: Potential use in linking imaging agents or diagnostic probes to targeting molecules.

Basic Information

Product Name	Mal-Peg4-Val-Cit-Pab-OH
CAS No.	2055041-39-7
Molecular Formula	C38H60N6O14
Molecular Weight	824.92 g/mol
Synonyms	Maleimide-PEG4-Val-Cit-PAB-OH; MC-Val-Cit-PAB-PEG4-OH; N-(Maleimidotriethyleneglycol)-Val-Cit-PAB-OH; (2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl) 2,5,8,11-tetraoxatetradecan-14-yl (2S)-2-[[(2S)-2-[[4-[(hydroxyamino)carbonyl]phenyl]methylcarbamoyl]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoate; Valine-Citrulline-PAB-PEG4-Maleimide; Cleavable ADC Linker (PEG4, Maleimide); VC-PAB-PEG4-Mal
EINECS	Contact for details

Quality Control

Our Mal-Peg4-Val-Cit-Pab-OH is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and conformity to specifications. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.