Description

Mal-Peg2-Val-Cit-Amido-Pab-Oh is a specialized, heterobifunctional polyethylene glycol (PEG) linker designed for the controlled conjugation of biomolecules. This compound matters for its precise cleavability and controlled release properties, which are critical for developing targeted therapeutic agents. Pharmaceutical researchers and bioconjugation specialists need this high-purity linker for advanced applications in antibody-drug conjugate (ADC) development, prodrug synthesis, and targeted drug delivery systems.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a key component in the construction of ADCs, connecting cytotoxic payloads to monoclonal antibodies via a protease-cleavable (Val-Cit) sequence for tumor-specific drug release.
• Prodrug Synthesis: Used to create prodrugs where the active pharmaceutical ingredient (API) is masked by the linker, which is cleaved by specific enzymes (e.g., cathepsin B) at the disease site.
• Targeted Drug Delivery Systems: Facilitates the development of ligand-directed therapeutics by conjugating drugs to targeting moieties like peptides, proteins, or antibodies.
• Bioconjugation & Protein Modification: The maleimide (Mal) group allows for stable thiol conjugation (e.g., to cysteine residues on proteins), while the PAB-OH group provides an attachment point for payloads containing a self-immolative spacer.
• Polymer-Drug Conjugates: Incorporated into polymer backbones to create advanced nanomedicines with enhanced solubility, pharmacokinetics, and controlled release profiles.
• Research & Development: A critical tool in academic and industrial R&D for exploring new targeted therapy paradigms and bioconjugation strategies.

Basic Information

Product Name	Mal-Peg2-Val-Cit-Amido-Pab-Oh
CAS No.	2055041-38-6
Molecular Formula	C₃₈H₅₈N₆O₁₄
Molecular Weight	810.91 g/mol
Synonyms	Maleimide-PEG2-Valine-Citrulline-PAB-OH; MC-Val-Cit-PAB-OH; Maleimidocaproyl-Val-Cit-PAB-OH; VC-PAB-Mal; Val-Cit-PAB-Maleimide; ADC Linker VC-PAB-Mal; Protease-Cleavable ADC Linker; (6-Maleimidocaproyl)valyl-citrullinyl-p-aminobenzyl alcohol
EINECS	Contact for details

Quality Control

Our Mal-Peg2-Val-Cit-Amido-Pab-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and bioconjugation. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, desiccate under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.