Description

n-(Mal-Peg6)-n-Bis(Peg3-Amine) Tfa Salt is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a maleimide group for thiol conjugation and two amine termini for further functionalization, presented as its trifluoroacetate salt. This compound is critical for creating stable, site-specific bioconjugates with controlled linker length and reduced immunogenicity. It is primarily utilized by researchers and manufacturers in biopharmaceutical development, particularly for antibody-drug conjugate (ADC) payload attachment, protein and peptide modification, and surface functionalization of nanoparticles and diagnostic reagents.

Application

• Antibody-Drug Conjugate (ADC) Linker: Site-specific conjugation of cytotoxic drugs to monoclonal antibodies via thiol-maleimide chemistry.
• Protein & Peptide PEGylation: Modification of therapeutic proteins to enhance solubility, prolong circulation half-life, and reduce immunogenicity.
• Diagnostic Reagent Conjugation: Linking enzymes, fluorophores, or other reporter molecules to antibodies or oligonucleotides for immunoassays and biosensors.
• Nanoparticle & Liposome Functionalization: Surface modification of drug delivery vehicles to attach targeting ligands or stealth PEG layers.
• Hydrogel & Biomaterial Crosslinking: Creating biocompatible matrices for tissue engineering and controlled drug release applications.
• Surface Chemistry & Immobilization: Crafting functionalized surfaces for microarray chips, biosensors, and affinity chromatography resins.

Basic Information

Product Name	n-(Mal-Peg6)-n-Bis(Peg3-Amine) Tfa Salt
CAS No.	2055040-99-6
Molecular Formula	C41H73F3N4O19
Molecular Weight	983.0 g/mol (Theoretical)
Synonyms	Mal-PEG6-Bis(PEG3-amine) TFA Salt; Maleimide-PEG6-tris-PEG3-amine TFA Salt; 1,1'-(2-(2-(2-(2-(2-(2-(3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethylazanediyl)bis(ethane-2,1-diyl) bis(2,2,2-trifluoroacetate); Heterobifunctional PEG Crosslinker, Mal-PEG6-amine2 TFA; PEG-based NHS Ester Alternative; Bifunctional PEG Reagent
EINECS	Contact for details

Quality Control

Our n-(Mal-Peg6)-n-Bis(Peg3-Amine) Tfa Salt is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and functional integrity. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and MS analysis. Our quality commitment supports applications in GMP-compatible bioconjugation processes and pre-clinical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC-MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (Maleimide)	≥ 90% of theoretical
Functional Group Assay (Amine, TFA Salt)	≥ 90% of theoretical
Solubility	Soluble in DMSO, DMF, acetonitrile, water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.