Description

3-((2-Chloropyrimidin-5-Yl)(Hydroxy)Methyl)Benzonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyrimidine-based molecular scaffold. This compound matters as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor research and development. Pharmaceutical R&D and fine chemical synthesis companies need this material for creating targeted therapies in oncology and other disease areas.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of kinase inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates.
• Chemical Biology Probes: Serves as a core structure for developing selective enzyme inhibitors used as research tools.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule production.
• Academic Research: Utilized in university and institutional labs for exploring new heterocyclic chemistry and bioactivity.

Basic Information

Product Name	3-((2-Chloropyrimidin-5-Yl)(Hydroxy)Methyl)Benzonitrile
CAS No.	2054952-82-6
Molecular Formula	C12H8ClN3O
Molecular Weight	245.66 g/mol
Synonyms	3-[(2-Chloropyrimidin-5-yl)(hydroxy)methyl]benzonitrile; 3-((2-Chloro-5-pyrimidinyl)(hydroxy)methyl)benzonitrile; 2-Chloro-5-[(3-cyanophenyl)(hydroxy)methyl]pyrimidine; 3-(Hydroxy(2-chloropyrimidin-5-yl)methyl)benzonitrile; Benzonitrile, 3-((2-chloro-5-pyrimidinyl)(hydroxy)methyl)-; 2054952-82-6
EINECS	Contact for details

Quality Control

Our 3-((2-Chloropyrimidin-5-Yl)(Hydroxy)Methyl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.