Description

2-(Chloromethyl)-5-Fluoropyrimidine Hydrochloride is a high-purity, halogenated pyrimidine derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its bifunctional reactivity, featuring both a chloromethyl group and a fluoropyrimidine core, which enables precise molecular construction. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated nucleoside analogs and other active pharmaceutical ingredients (APIs) with potential antiviral or anticancer activity.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that leverage the fluoropyrimidine scaffold for enhanced bioactivity.
• Chemical Biology & Proteomics: Employed as a versatile linker or functionalization reagent in the development of chemical probes and affinity tags.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of specialty polymers and functional materials.
• Academic & Contract Research: Serves as a valuable reagent for methodological studies in organic chemistry and medicinal chemistry within university and CRO laboratories.

Basic Information

Product Name	2-(Chloromethyl)-5-Fluoropyrimidine Hydrochloride
CAS No.	2052356-33-7
Molecular Formula	C5H5Cl2FN2
Molecular Weight	199.01 g/mol
Synonyms	5-Fluoro-2-(chloromethyl)pyrimidine hydrochloride; 2-(Chloromethyl)-5-fluoropyrimidine HCl; 5-Fluoro-2-(chloromethyl)pyrimidine HCl salt; 2-Chloromethyl-5-fluoropyrimidine hydrochloride; (5-Fluoropyrimidin-2-yl)methyl chloride hydrochloride; 2052356-33-7; 2-(Chloromethyl)-5-fluoropyrimidine monohydrochloride
EINECS	Contact for details

Quality Control

Our 2-(Chloromethyl)-5-Fluoropyrimidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.