Description

1-(2-Chloropyrimidin-4-Yl)-5-Fluoro-3-Methyl-1H-Benzo[D]Imidazol-2(3H)-One is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of novel active pharmaceutical ingredients (APIs). This compound matters because it provides a critical, structurally complex building block essential for modern drug discovery programs, particularly in oncology and targeted therapies. Pharmaceutical R&D teams and fine chemical manufacturers need this precise intermediate to develop next-generation small molecule drugs with improved efficacy and selectivity.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel kinase inhibitors and other targeted cancer therapeutics.
• Organic Synthesis Building Block: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Research & Development: Serves as a critical reagent in academic and industrial research focused on heterocyclic chemistry and drug discovery.
• API Manufacturing: Employed in the scaled-up synthesis of active pharmaceutical ingredients under current Good Manufacturing Practice (cGMP) conditions.

Basic Information

Product Name	1-(2-Chloropyrimidin-4-Yl)-5-Fluoro-3-Methyl-1H-Benzo[D]Imidazol-2(3H)-One
CAS No.	2050908-30-8
Molecular Formula	C₁₄H₉ClFN₅O
Molecular Weight	317.71 g/mol
Synonyms	1-(2-Chloropyrimidin-4-yl)-5-fluoro-3-methyl-1,3-dihydro-2H-benzimidazol-2-one; 5-Fluoro-3-methyl-1-(2-chloropyrimidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 1-(2-Chloro-4-pyrimidinyl)-5-fluoro-3-methyl-2-benzimidazolinone; 2050908-30-8; Benzo[d]imidazol-2(3H)-one, 1-(2-chloro-4-pyrimidinyl)-5-fluoro-3-methyl-; 1-(2-Chloropyrimidin-4-yl)-5-fluoro-3-methyl-1H-benzo[d]imidazol-2(3H)-one
EINECS	Contact for details

Quality Control

Our 1-(2-Chloropyrimidin-4-Yl)-5-Fluoro-3-Methyl-1H-Benzo[D]Imidazol-2(3H)-One is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical R&D. All batches are supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization, ensuring the material meets the stringent requirements for advanced intermediate use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.