Description

Fmoc-D-Arg(Me,Pbf)-OH is a high-purity, orthogonally protected derivative of D-arginine, designed for advanced solid-phase peptide synthesis (SPPS). This non-natural amino acid building block is critical for introducing modified arginine residues with enhanced stability and specific side-chain functionality into complex peptide sequences. It is an essential raw material for pharmaceutical R&D, particularly in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes targeting proteases and protein-protein interactions.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the controlled incorporation of methylated D-arginine into peptide chains.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, including protease inhibitors, receptor agonists/antagonists, and antimicrobial peptides.
• Peptidomimetic Design: Serves as a building block for creating stable peptide analogs with improved metabolic stability and binding affinity.
• Bioconjugation and Probe Synthesis: Facilitates the creation of labeled peptides for diagnostic imaging, target identification, and biochemical assays.
• Academic & Industrial Research: Employed in studies of protein structure-function relationships, enzyme kinetics, and signal transduction pathways.

Basic Information

Item	Details
Product Name	Fmoc-D-Arg(Me,Pbf)-OH
CAS No.	2044711-16-0
Molecular Formula	C33H45N5O7S
Molecular Weight	655.81 g/mol
Synonyms	Fmoc-D-NG-Methyl-NG-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)arginine; N-α-Fmoc-Nω-methyl-Nω-(Pbf)-D-arginine; Fmoc-D-Arg(Me,Pbf)-OH; Fmoc-D-NG-Methyl-NG-(Pbf)arginine; (2R)-5-[[(2,2,4,6,7-Pentamethyl-2,3-dihydro-1-benzofuran-5-yl)sulfonyl](methyl)amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid; Fmoc-D-Arg(Me,Pbf)-OH CAS 2044711-16-0; Fmoc-D-NG-Methyl-NG-(Pbf)-L-arginine (enantiomer); Fmoc-D-Arg(NG-Me,NG-Pbf)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-D-Arg(Me,Pbf)-OH is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for sensitive peptide synthesis. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a corresponding Certificate of Analysis (COA). We support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.