Description

Fmoc-n-Me-Hoarg(Pbf)-Oh CAS NO 2044711-15-9 is a protected, non-natural amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This high-purity building block is critical for researchers and manufacturers developing complex peptides with enhanced stability and specific biological activity. It is an essential raw material for pharmaceutical R&D, particularly in the production of therapeutic peptides and peptidomimetics for drug discovery programs.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the sequential assembly of peptide chains on resin.
• Pharmaceutical Research & Development: For the discovery and synthesis of novel therapeutic peptide candidates targeting various diseases.
• Peptidomimetic Design: Used to incorporate modified arginine analogs that can improve metabolic stability and binding affinity of peptide drugs.
• Bioconjugation: Serves as a specialized linker or modified residue in the creation of peptide-protein or peptide-small molecule conjugates.
• Chemical Biology Probes: Essential for synthesizing labeled or tagged peptides used in studying protein-protein interactions and cellular pathways.
• API Intermediate Manufacturing: Acts as a critical intermediate in the cGMP-compliant production of Active Pharmaceutical Ingredients (APIs) for peptide-based therapeutics.

Basic Information

Product Name	Fmoc-n-Me-Hoarg(Pbf)-Oh
CAS No.	2044711-15-9
Molecular Formula	C33H45N5O8S
Molecular Weight	671.81 g/mol
Synonyms	Fmoc-N(omega)-methyl-N(omega)-[(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)]-L-homoarginine; Fmoc-NG-Methyl-NG-(Pbf)-L-homoarginine; N-α-Fmoc-NG-methyl-NG-(Pbf)-homoarginine; Fmoc-NG-Me-NG-(Pbf)-homoArg-OH; Fmoc-Homoarginine(NG-Me, NG-Pbf)-OH; (2S)-5-[[[N-Methyl-[(2,2,4,6,7-pentamethyldihydrobenzofuran-5-yl)sulfonyl]amino]imino]methyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-n-Me-Hoarg(Pbf)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding pharmaceutical research. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.