Description

(R)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-Morpholinopropanoic Acid is a high-purity, non-natural amino acid derivative featuring a chiral center and a protected amine group. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, enabling the introduction of a morpholine moiety to modulate physicochemical properties and biological activity. It is primarily utilized by pharmaceutical research organizations and fine chemical manufacturers engaged in the development of novel therapeutic agents, including protease inhibitors and targeted drug conjugates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the solid-phase and solution-phase synthesis of peptide-based active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Used to incorporate a morpholine ring into peptide backbones to enhance metabolic stability, solubility, and receptor binding affinity.
• Protease Inhibitor Development: Serves as a core structural component in the design of inhibitors for various proteolytic enzymes.
• Chemical Biology Probes: Employed in the synthesis of labeled peptides and activity-based probes for studying enzyme function and cellular pathways.
• Conjugation Chemistry: The Fmoc-protected amine and carboxylic acid functionalities allow for selective conjugation and further chemical elaboration.
• Academic & Contract Research: Essential for research institutions and CROs exploring new peptide architectures and drug discovery platforms.

Basic Information

Product Name	(R)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-Morpholinopropanoic Acid
CAS No.	2044710-70-3
Molecular Formula	C22H24N2O5
Molecular Weight	396.44 g/mol
Synonyms	Fmoc-(R)-3-morpholinylalanine; Fmoc-D-Morpholinoalanine; (R)-2-(Fmoc-amino)-3-morpholinopropanoic acid; Fmoc-D-Mor; Fmoc-D-MorphAla-OH; (R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-morpholinepropionic Acid; N-α-Fmoc-N-ω-Morpholino-D-alanine
EINECS	Contact for details

Quality Control

Our (R)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-Morpholinopropanoic Acid is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with pharmaceutical-grade standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.