Description

Fmoc-(4,(Pbf)-Guanido)Phe-OH is a protected, non-natural amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound matters as a critical building block for introducing the unique guanidino functional group into peptide chains, enabling the creation of peptides with enhanced binding affinity and specificity. It is primarily needed by researchers and manufacturers in the pharmaceutical and biotechnology industries developing novel therapeutic peptides, protease inhibitors, and diagnostic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides.
• Pharmaceutical Research: Used in the development of peptide-based drugs targeting enzymes like proteases.
• Bioconjugation: Serves as a precursor for creating peptide conjugates with other biomolecules or labels.
• Chemical Biology Probes: Enables the study of protein-protein interactions and enzyme mechanisms.
• Library Synthesis: A valuable component for generating combinatorial peptide libraries for screening.
• GPCR Ligand Development: Used in synthesizing peptide analogs that interact with G-protein coupled receptors.

Basic Information

Product Name	Fmoc-(4,(Pbf)-Guanido)Phe-OH
CAS No.	2044710-32-7
Molecular Formula	C₃₃H₃₇N₅O₇S
Molecular Weight	647.74 g/mol
Synonyms	Fmoc-(4-(Pbf-guanidino))phenylalanine; Fmoc-4-((2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl)guanidino)-L-phenylalanine; N-α-Fmoc-N-ω-(Pbf)-L-arginine(4-phenylalanine) derivative; Fmoc-Arg(Pbf)-Phe-OH analog; Protected guanidinophenylalanine; SPPS amino acid building block; Fmoc-Phe(4-guanidino(Pbf))-OH
EINECS	Contact for details

Quality Control

Our Fmoc-(4,(Pbf)-Guanido)Phe-OH is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed in a desiccated environment to prevent moisture uptake, which can affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.